Evidence map›Paper›PMID 42667058›Full record

ArticleBrain circulation

Exosomal programmed death-ligand 1 is associated with post-intracerebral hemorrhage pneumonia.

Bin Gao, Ying Zhang, Nuo Cheng, Shunnan Ge, Zhichao Lu, Hong Wang, Wenyan He, Wei Shi, Yan Qu, Xingquan Zhao and 2 more

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In one paragraph

Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bin Gao *Department of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ying Zhang *Department of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Nuo ChengDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Shunnan GeDepartment of Neurosurgery, Tangdu Hospital, Airforce Medical University, Xi'an, China.
Zhichao LuDepartment of Neurosurgery, Nantong University Affiliated Hospital, Nantong, China.
Hong WangDepartment of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing, China.
Wenyan HeDepartment of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei ShiDepartment of Neurosurgery, Nantong University Affiliated Hospital, Nantong, China.
Yan QuDepartment of Neurosurgery, Tangdu Hospital, Airforce Medical University, Xi'an, China.
Xingquan ZhaoDepartment of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Fu-Dong ShiDepartment of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Kaibin ShiDepartment of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-stroke immunosuppression elevates the risk of stroke-associated pneumonia (SAP). Our earlier research indicated that perihematomal neuron-derived PD-L1 may play a role in peripheral immunosuppression following intracerebral hemorrhage (ICH); however, the specific carriers of PD-L1 and its potential as a predictor for SAP risk are yet to be determined. MATERIALS AND

methodsWe hypothesize that elevated levels of exosomal PD-L1 in peripheral blood after ICH mediate immune suppression and increase the risk of SAP. This observational study aimed to investigate the levels of exosomal PD-L1 post-ICH and their relationship with SAP. In an exploratory cohort of 39 patients with ICH and 24 healthy controls and a validation cohort of 144 patients with ICH.

resultsAt admission, patients with ICH exhibited significantly increased exosome numbers in their peripheral blood, with these exosomes showing high expression of the neuronal marker neural cell adhesion molecule L1, suggesting a brain origin. Exosomal PD-L1 levels were elevated in patients with ICH compared to healthy controls and were higher in patients with SAP than those without. After adjusting for confounders, exosomal PD-L1 was confirmed to be independently associated with SAP in both the exploratory cohort and validation cohort.

conclusionsBrain-derived exosomes with high expression of PD-L1 are substantially released into the periphery after ICH. Elevated exosomal PD-L1 levels correlate with an increased risk of SAP.

Indexed as

Exosomeintracerebral hemorrhagepredictionprogrammed cell death ligand 1stroke-associated pneumonia

Identifiers

PMID42667058
PMCPMC13524406

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