ArticleThe journal of venomous animals and toxins including tropical diseases2026
Proteomic profiling and comparative hemotoxicity of
Article in The journal of venomous animals and toxins including tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Snakebite envenomation caused by Methods: We performed an integrated comparative analysis combining nano-LC-MS/MS proteomics with multi-target functional assays to systematically evaluate venom composition and biological activities. Proteomic profiling was used to characterize toxin family abundance, while enzymatic, cytotoxic, hemolytic, and cell signaling assays were conducted to assess functional effects. Results: Proteomic analysis revealed that both venoms are predominantly composed of hemotoxic toxin families, including snake venom metalloproteinases (SVMP), snake venom serine proteases (SVSP), C-type lectin-like proteins (CTLP), and phospholipase A₂ (PLA₂), with broadly comparable relative abundances. Functional assays demonstrated similar concentration-dependent patterns in proteolytic, PLA₂, thrombin-like, and fibrinolytic activities, with no statistically significant interspecific differences. Both venoms also induced comparable cytotoxic effects across mammalian cell lines, while exhibiting limited hemolytic activity and minimal modulation of Ca²⁺ signaling and nitric oxide production. Conclusions: These findings demonstrate that
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