Evidence map›Paper›PMID 42667039›Full record

ArticleIDCases2026

Disseminated varicella-zoster virus infection with gastrointestinal prodromal symptoms during daratumumab therapy for relapsed and refractory multiple myeloma.

Yuichi Horigome, Yusuke Michishita, Momo Tanaka, Takuro Yanagida, Hiroaki Konishi, Koichi Ehata, Kei Hayama, Hirotoshi Kamata, Koji Miyazaki, Takahiro Suzuki

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuichi HorigomeDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Yusuke MichishitaDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Momo TanakaDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Takuro YanagidaDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Hiroaki KonishiDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Koichi EhataDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Kei HayamaDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Hirotoshi KamataDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.
Koji MiyazakiDepartment of Transfusion and Cell Transplantation, Kitasato University School of Medicine, Sagamihara, Japan.
Takahiro SuzukiDepartment of Hematology, Kitasato University School of Medicine, Sagamihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicella-zoster virus (VZV) reactivation is a recognized complication in patients with multiple myeloma, particularly during treatment-associated immunosuppression. Although disseminated VZV infection is uncommon, delayed diagnosis may result in life-threatening disease. We report a Japanese woman in her 70s with relapsed and refractory multiple myeloma who developed anorexia, vomiting, and fever before the appearance of disseminated vesicular eruptions during daratumumab-based therapy. Laboratory findings showed cytopenia, marked liver dysfunction, and hypogammaglobulinemia. Disseminated VZV infection was confirmed by antigen testing, and prompt intravenous acyclovir resulted in clinical recovery. This case highlights that disseminated VZV infection may initially present with gastrointestinal symptoms before characteristic skin lesions during anti-CD38-based therapy, representing an important diagnostic pitfall. Early recognition, prompt antiviral therapy, and consideration of antiviral prophylaxis may help reduce the risk of severe disease.

Indexed as

Antiviral prophylaxisDaratumumabDisseminated infectionGastrointestinal symptomsMultiple myelomaVaricella-zoster virus

Identifiers

PMID42667039
PMCPMC13524447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.