ArticleBioinformatics advances2026
unsurv: clustering individualized survival curves.
Article in Bioinformatics advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Motivation: Biomedical phenotyping workflows often cluster high-dimensional molecular or clinical covariates and then test survival differences post hoc. This can miss structure that is expressed primarily through the timing of risk, because two patients may have similar scalar risk at one horizon but different predicted survival trajectories. Many survival learners can output patient-specific curves Results: We introduce unsurv, an R package that clusters individualized survival curves on a common time grid using validity-preserving preprocessing, time-weighted integral distances, and partitioning around medoids (PAM). The output includes observed medoid prototype curves, a nearest-medoid rule for assigning new patients, model-selection summaries, resampling-based stability using the Adjusted Rand Index (ARI), and a new unsurv_compare() function for comparing partitions against baselines. The package is model-agnostic and can be paired with any survival learner that returns Availability and implementation: The unsurv package is available on CRAN and its full source code and documentation are provided at https://github.com/ielbadisy/unsurv under the MIT License.
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