ArticleJournal of current ophthalmology
Comparison of Choroidal Vascular Index Measurements in Pachychoroid Pigment Epitheliopathy using Manual ImageJ-Based Niblack and Protocol-Standardized Otsu Thresholding.
Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To compare choroidal vascular index (CVI) measurements obtained using manual ImageJ-based Niblack thresholding and protocol-standardized Otsu thresholding in patients with pachychoroid pigment epitheliopathy (PPE), employing a full-length choroidal region of interest (ROI) approach. Methods: This retrospective observational study included 30 eyes of 30 patients diagnosed with PPE. Enhanced depth imaging-optical coherence tomography (EDI-OCT) scans were acquired using Heidelberg Spectralis. Both horizontal and vertical fovea-centered B-scans were analyzed. The ROI was manually delineated on the OCT device using the polygon selection tool to include the entire visible choroid from the retinal pigment epithelium/Bruch's membrane complex to the choroidoscleral junction across the full scan width. CVI was calculated as the ratio of luminal area-to-total choroidal area. Manual ImageJ-based Niblack local thresholding was compared with protocol-standardized Otsu global thresholding using identical manually defined ROIs. Agreement was evaluated using paired Results: A total of 60 OCT B-scans were analyzed. Mean CVI values were 0.615 ± 0.030 for ImageJ-Niblack and 0.626 ± 0.052 for Otsu thresholding. The mean intermethod difference was +0.011 ± 0.028, with no statistically significant difference between methods ( Conclusions: Protocol-standardized Otsu thresholding yielded CVI measurements that were directionally consistent with manual ImageJ-based Niblack analysis in PPE when a full-length choroidal ROI strategy was applied. This approach may support standardized group-level research analyses, but it should not be interpreted as establishing accuracy equivalence or full clinical interchangeability.
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