Evidence map›Paper›PMID 42667011›Full record

ArticleNeurosurgery practice2026

Outcomes of Laser Interstitial Thermal Therapy-Augmented Surgery in the Management of Subcortical Glioblastoma.

Hsien-Chung Chen, Anudeep Yekula, Marcus W Weimar, Eric T Wong, Sasmit Sarangi, Heinrich Elinzano, Andrew S Venteicher, Clark C Chen

Abstract read
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In one paragraph

Article in Neurosurgery practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hsien-Chung ChenDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0002-4387-0167
Anudeep YekulaDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
Marcus W WeimarDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA.
Eric T WongDepartment of Neurology, Medicine, Neurosurgery and Radiation Oncology, Brown University Health & Rhode Island Hospital, Providence, Rhode Island, USA.
Sasmit SarangiDepartment of Neurology, Medicine, Neurosurgery and Radiation Oncology, Brown University Health & Rhode Island Hospital, Providence, Rhode Island, USA.
Heinrich ElinzanoDepartment of Neurology, Medicine, Neurosurgery and Radiation Oncology, Brown University Health & Rhode Island Hospital, Providence, Rhode Island, USA.
Andrew S VenteicherDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-0643-0493
Clark C ChenDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0001-9544-2570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSubcortical glioblastomas present surgical challenges owing to their proximity to critical anatomy. In this study, we assessed the utility of laser interstitial thermal therapy (LITT) in the management of subcortical glioblastomas.

methodsClinical outcomes were evaluated in 80 consecutive patients with subcortical glioblastoma (isocitrate dehydrogenase wild-type, H3K27 nonmutant) treated surgically between 2017 and 2025. During this time period, LITT was increasingly incorporated into stereotactic needle biopsy (SNB) and surgical resection (SR) workflows, enabling comparisons between SNB vs SNB + LITT and between SR only vs planned subtotal resection (STR) + LITT.

resultsAmong 46 treatments involving SNB, 24 underwent SNB only and 22 SNB + LITT. Lesion size was similar between these groups (1.72 ± 0.38 vs 1.92 ± 0.36 cm,

conclusionOur results support incorporating LITT as a staged procedure into planned STR or in conjunction with SNB in the management of subcortical glioblastoma. Postoperative motor deficit is associated with poor survival outcomes.

Indexed as

Laser interstitial thermal ablationResectionStereotactic needle biopsySubcortical glioblastomas

Identifiers

PMID42667011
PMCPMC13524153

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.