Evidence map›Paper›PMID 42666893›Full record

ArticleMaterials today. Bio2026

Thiol-mediated ROS-responsive hydrogel with arginine-driven NO cascade for colitis treatment.

Shuang Liu, Zhongming Zhao, Ziyi Wang, Xianghe Pi, Weiqin Zhao, Huiju Hu, Xinmei He, Pengcheng Che, Junjie Li, Hong Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuang LiuDepartment of Basic Medical Sciences, North China University of Science and Technology, Tangshan, 063210, China.
Zhongming ZhaoSchool of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, China.
Ziyi WangHebei Key Laboratory for Rehabilitation Engineering and Regenerative Medicine, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, 063210, China.
Xianghe PiHebei Key Laboratory for Rehabilitation Engineering and Regenerative Medicine, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, 063210, China.
Weiqin ZhaoHebei Key Laboratory for Rehabilitation Engineering and Regenerative Medicine, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, 063210, China.
Huiju HuHebei Key Laboratory for Rehabilitation Engineering and Regenerative Medicine, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, 063210, China.
Xinmei HeHebei Key Laboratory for Rehabilitation Engineering and Regenerative Medicine, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, 063210, China.
Pengcheng CheHebei Key Laboratory for Rehabilitation Engineering and Regenerative Medicine, School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, 063210, China.
Junjie LiSchool of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, China.
Hong SunDepartment of Basic Medical Sciences, North China University of Science and Technology, Tangshan, 063210, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing integrated, drug-free therapeutic platforms that simultaneously address oxidative stress, immune dysregulation, and gut microbiota dysbiosis remains a significant challenge in UC management. Although hydrogels offer localized delivery advantages, their clinical versatility is frequently hindered by a reliance on exogenous drug encapsulation. To overcome this limitation, we developed a multifunctional, ROS-responsive hydrogel (ODCAS) that functions as an inherently bioactive platform. The ODCAS network is constructed via dynamic Schiff base crosslinking between ODex and thiolated arginine chitosan, further reinforced by ROS-triggered disulfide bonds leveraging. This sophisticated architecture undergoes ROS-responsive programmed degradation, driving

Indexed as

Gut microbiotaIntestinal epithelial barrierNitric oxideReactive oxygen speciesUlcerative colitis

Identifiers

PMID42666893
PMCPMC13524505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.