Evidence map›Paper›PMID 42666879›Full record

ArticleHeart rhythm O22026

Terbutaline for sinus node dysfunction after heart transplantation.

Ersilia M DeFilippis, William Tate, Alice Chung, Jose L Batista, Jaya Batra, Matthew Regan, Youssef A Elnabawi, Elena M Donald, Elaine Y Wan, Angelo Biviano and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ersilia M DeFilippisDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
William TateDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Alice ChungDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Jose L BatistaDivision of Cardiovascular Disease, University of Miami Miller School of Medicine, JFK Medical Center, Palm Beach, Florida.
Jaya BatraDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Matthew ReganDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Youssef A ElnabawiDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Elena M DonaldDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Elaine Y WanDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Angelo BivianoDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Geoffrey RubinDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
David MajureDivision of Cardiology, Department of Medicine, New York Presbyterian-Weill Cornell Medical Center, New York, New York.
Farhana LatifDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Koji TakedaDivision of Cardiac Surgery, Department of Surgery, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Kevin J ClerkinDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Gabriel SayerDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Nir UrielDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.
Hirad YarmohammadiDivision of Cardiology, Department of Medicine, New York Presbyterian-Columbia University Irving Medical Center, New York, New York.

Funding

Understanding the role of mitochondrial dysfunction in cardiac arrhythmias using a novel 3D panoramic optical mapping systemR01HL152236 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAN, ELAINE Y · 2020 to 2024
$2.0M
Identifying Novel Diagnostics and Mechanisms for Cardiac Allograft VasculopathyK23HL148528 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLERKIN, KEVIN J · 2020 to 2024
$852k
NHLBI NIH HHS K23 HL148528NHLBI NIH HHS R01 HL152236
6 · The paper itself

Abstract

Background: Early sinus node dysfunction (SND) occurs in 2%-4% of patients following heart transplantation (HT). Objective: The purpose of the current study was to examine characteristics of patients requiring terbutaline for SND post-HT and clinical and hemodynamic outcomes. Methods: A retrospective study was conducted at 2 centers to identify HT recipients from January 2020 to June 2025 started on terbutaline for early SND. Data was collected regarding recipient and donor characteristics and compared between terbutaline and no terbutaline groups. For the terbutaline group, additional information was obtained regarding changes in hemodynamics, dosing, and tolerability. Response to terbutaline after steady-state dosing and sinus node recovery were assessed. Results: 450 individuals underwent bicaval HT (median age 56 years, 75% male, 23% black, 18% Hispanic). Of these, 30 (6.7%) were initiated on terbutaline an average of 7 days post-HT. Demographics, pre-transplant mechanical circulatory support, or pre-transplant amiodarone exposure were similar between groups. Older donor age, longer ischemic time, and Organ Care System use were significantly associated with terbutaline use. Heart rate and cardiac index by Fick significantly increased after starting terbutaline with significant individual variability. 50% were classified as having sinus node recovery; 2 patients ultimately needed a permanent pacemaker. Conclusion: Despite individual variability in heart rate response with terbutaline, early SND was able to be managed pharmacologically in most patients and need for permanent pacemaker remained low.

Indexed as

Heart rateHeart transplantationPermanent pacemakerSinus node dysfunctionTerbutaline

Identifiers

PMID42666879
PMCPMC13523582

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.