Evidence map›Paper›PMID 42666871›Full record

ArticleACS central science2026

Spatial Evolution of Antimicrobial Metallopolymers toward the Main Chain Topology.

Md Waliullah Hossain, Marsh Kral, Aylin Feuerstein, Swagatam Barman, Alimi Abiodun, Markus Gallei, Chao Cai, André Schäfer, Chuanbing Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Md Waliullah HossainDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Marsh KralDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Aylin FeuersteinDepartment of Chemistry, Faculty of Natural Sciences and Technology, Saarland University, 66123 Saarbrücken, Germany.ORCID https://orcid.org/0000-0003-1930-6264
Swagatam BarmanDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Alimi AbiodunDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Markus GalleiDepartment of Chemistry, Faculty of Natural Sciences and Technology, Saarland University, 66123 Saarbrücken, Germany.ORCID https://orcid.org/0000-0002-3740-5197
Chao CaiClinical Pharmacy and Outcomes Sciences (CPOS), College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States.
André SchäferDepartment of Chemistry, Faculty of Natural Sciences and Technology, Saarland University, 66123 Saarbrücken, Germany.ORCID https://orcid.org/0000-0002-5969-6618
Chuanbing TangDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID https://orcid.org/0000-0002-0242-8241

Funding

Engineering Cationic Metallopolymers to Potentiate Antibiotics via Multiple MechanismsR01EB038047 · NIBIB · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Chuanbing Tang · 2025 to 2026
$1.1M
NIBIB NIH HHS R01 EB038047
6 · The paper itself

Abstract

Synthetic polymers and peptides with spatial control have emerged as effective molecular agents for addressing antimicrobial resistance (AMR). We report on one of the first kinds of studies on how spatial compositions in cationic metallopolymers can be tuned to control their antimicrobial efficacy. As a representative, the evolution of cobaltocenium cation from side chain to main chain has shown drastic impacts on polymer-cell interactions and consequential killing of microbes. A main-chain cobaltocenium polymer exhibited broad-spectrum activity against multidrug-resistant (MDR) bacteria, primarily targeting bacterial cell membranes and outer leaflets. The polymer also showed a strong efficacy in treating mature biofilms across multiple bacterial strains. Resistance development was evaluated over 20 passages, with no detectable resistance. Overall, these findings reveal spatial control of cationic centers in metallopolymers as a unique molecular platform for combating MDR pathogens and alleviating the AMR burden on global healthcare settings.

Identifiers

PMID42666871
PMCPMC13523504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.