Evidence map›Paper›PMID 42666858›Full record

ArticleBrain circulation

Early antiplatelet therapy was associated with reduced neurological deterioration in stroke patients treated with intravenous thrombolysis.

Jing Wang, Min Zhao, Haijuan Kang, Sijie Li, Di Wu, Hongrui Ma, Longfei Wu, Guiyou Liu, Haiqing Song, Qingfeng Ma and 2 more

Abstract read
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In one paragraph

Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jing Wang *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Min Zhao *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Haijuan Kang *Department of Neurology, Beijing Fengtai Hospital of Integrated Traditional Chinese and Modern Medicine, Beijing, China.
Sijie LiDepartment of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China.
Di WuChina-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hongrui MaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Longfei WuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Guiyou LiuBeijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Haiqing SongDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qingfeng MaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xunming JiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wenbo ZhaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) are at high risk of early neurological deterioration (END) due to increased platelet activation.

objectivesThe objective of the study was to investigate the safety and efficacy of early antiplatelet therapy in reducing END postthrombolysis, and identify patients who may benefit.

methodsIn this observational study, AIS patients receiving IVT were stratified into the early tirofiban group and the control group according to antiplatelet therapy during the first 24 h following IVT. The primary endpoint was END

resultsOf the 319 patients enrolled, 66 in the early tirofiban group and 120 matched controls were analyzed. END

conclusionEarly tirofiban therapy following IVT was associated with reduced END without increased bleeding risk. Specific patient subgroups may potentially benefit from early antiplatelet therapy, further confirmation is needed.

Indexed as

Acute ischemic strokeearly neurological deteriorationintravenous thrombolysistirofiban

Identifiers

PMID42666858
PMCPMC13524403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.