ReviewJournal of current ophthalmology
Outcomes of Vitreoretinal Surgery for X-Linked Retinoschisis: A Systematic Review and Meta-Analysis of the Current Literature.
Review in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To systematically review and meta-analyze the outcomes of vitreoretinal surgery for X-linked retinoschisis (XLRS)-related complications. Methods: A systematic search of PubMed, Cochrane Library, CINAHL, Web of Science, and OVID was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Studies reporting surgical outcomes in patients with XLRS-associated retinal detachment or schisis were included. Primary outcomes were anatomic success (primary and final reattachment rates) and best-corrected visual acuity (BCVA). Random-effects meta-analysis was performed using RevMan. Subgroup analyses by surgical approach and age group were prespecified, and their feasibility was assessed according to the number of contributing studies. Results: Fourteen studies comprising over 200 eyes were included. The pooled primary reattachment rate was 0.73 (95% confidence interval [CI]: 0.46-0.99; Conclusions: Vitreoretinal surgery for XLRS-related complications can achieve favorable final anatomical outcomes in most cases, although multiple procedures are frequently required and visual recovery is variable and often modest. Anatomical success does not guarantee functional recovery, underscoring the importance of realistic prognostic counseling. These findings should be interpreted with caution, given that all included studies are small, observational case series with significant clinical heterogeneity. Standardized, prospective, multicenter studies are needed to optimize surgical strategies in this population.
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