Evidence map›Paper›PMID 42666827›Full record

ArticleACS central science2026

Programmed S → N Remote Cyano Migration: A Thiocyanate-Based Entry to Cyanamides and Selective Ferroptosis Inducers.

Xiyan Duan, Wanjing Feng, Fengjiao Du, Can Liu, Ning Liu, Yihao Zhao, Kun Liu, Pu Liu, Yixuan Zhang, Jingze Li and 2 more

Abstract read
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In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiyan DuanSchool of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China.ORCID https://orcid.org/0000-0003-4882-0430
Wanjing FengCollege of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Fengjiao DuSchool of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China.
Can LiuCollege of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Ning LiuSchool of Nursing, Henan University of Science and Technology, Luoyang 471003, Henan, China.
Yihao ZhaoSchool of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China.
Kun LiuSchool of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China.
Pu LiuCollege of Food & Bioengineering, Henan University of Science and Technology, Luoyang 471003, Henan, China.ORCID https://orcid.org/0000-0002-4841-9965
Yixuan ZhangSchool of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China.
Jingze LiSchool of Chemistry & Chemical Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China.
Yahui DingCollege of Chemistry, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.ORCID https://orcid.org/0000-0001-8588-7728
Quan ZhangCollege of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.ORCID https://orcid.org/0000-0001-5280-0956

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis represents a promising strategy to overcome apoptosis-associated drug resistance, yet access to diverse and drug-like ferroptosis-inducing chemical space remains limited. Among potential scaffolds for populating this high-value space, cyanamide-bearing molecules are attractive but synthetically challenging due to the long-standing difficulty of constructing the N-CN bond. Here we disclose a thiocyanate-enabled cascade cyclization that leverages inexpensive, low-toxicity inorganic thiocyanate as an unconventional electrophilic CN surrogate. This transformation proceeds through a cascade sequence involving SCN installation, remote S → N cyano migration, and subsequent intramolecular thiazine annulation under mild, metal-free conditions. The resulting cyanamide 3,4-dihydro-2H-1,4-thiazines exhibited nanomolar ferroptosis-inducing potency; lead compounds

Identifiers

PMID42666827
PMCPMC13523506

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.