Evidence map›Paper›PMID 42666688›Full record

ArticleEClinicalMedicine2026

The effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on binge eating in patients with obesity: a systematic review and meta-analysis.

Isobel Emptage, Stella Kozmér, Antemeka Cobham-Wilson, Bernardo Sousa, Kirsty Sugden, Lauren Wheeler, Clare Llewellyn, Janine Makaronidis, Cynthia Bulik, Francesca Solmi and 1 more

Abstract read
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In one paragraph

Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Isobel EmptageDivision of Psychiatry, University College London, London, United Kingdom.
Stella KozmérDepartment of Health and Community Sciences, Medical School, University of Exeter, Exeter, United Kingdom.
Antemeka Cobham-WilsonDivision of Psychiatry, University College London, London, United Kingdom.
Bernardo SousaDivision of Psychiatry, University College London, London, United Kingdom.
Kirsty SugdenDivision of Psychiatry, University College London, London, United Kingdom.
Lauren WheelerDivision of Psychiatry, University College London, London, United Kingdom.
Clare LlewellynDepartment of Behavioural Science and Health, University College London, London, United Kingdom.
Janine MakaronidisCentre for Obesity Research, Division of Medicine, University College London, London, United Kingdom.
Cynthia BulikDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Francesca SolmiDivision of Psychiatry, University College London, London, United Kingdom.
Ilaria CostantiniDivision of Psychiatry, University College London, London, United Kingdom.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), widely used for weight management and type 2 diabetes, may reduce binge eating behaviours and body dissatisfaction, but there are concerns that they might increase eating restraint. We evaluated the effectiveness of GLP-1RAs for binge eating severity and related eating behaviours. Methods: We conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing any GLP-1RA with placebo or active comparators reporting validated measures of binge eating, disinhibited eating, and loss of control eating. We searched MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials for RCTs published from Jan 2005 to April 2026. Trials including participants with severe physical comorbidities (e.g., cancer) were excluded. Standardised mean differences (Hedges' Findings: Twenty five RCTs (n = 8069; ∼two-thirds female; majority White) met inclusion criteria. Compared with control conditions, participants allocated to GLP-1RAs reported moderate reductions in binge eating (n = 2106; k = 9; Interpretation: GLP-1RAs reduced binge eating-related behaviours and emotional eating and increased cognitive or dietary restraint, though whether restraint is pathological is unclear. Given heterogeneity and high risk of bias, adequately powered trials targeting individuals with diagnosed binge eating disorder and longer follow-up are needed to inform clinical practice. Funding: Wellcome Trust and Medical Research Foundation.

Indexed as

Binge eating disorderEating behaviourGLP-1 receptor agonistsObesityRandomised controlled trialsSystematic review and meta-analysis

Identifiers

PMID42666688
PMCPMC13523834

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.