Electric-Field Catalysis of Diels-Alder Reactions.

Bing-Ru Shao, Shen-Yi Guo, Miguel Paraja, Qing-Xia Zhang, Augustina Jozeliu̅naitė, Naomi Sakai, Stefan Matile

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Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Bing-Ru ShaoDepartment of Organic Chemistry, University of Geneva, 1211 Geneva, Switzerland.

Shen-Yi GuoDepartment of Organic Chemistry, University of Geneva, 1211 Geneva, Switzerland.

Miguel ParajaDepartment of Organic Chemistry, University of Geneva, 1211 Geneva, Switzerland.

Qing-Xia ZhangDepartment of Organic Chemistry, University of Geneva, 1211 Geneva, Switzerland.

Augustina Jozeliu̅naitėDepartment of Organic Chemistry, University of Geneva, 1211 Geneva, Switzerland.ORCID https://orcid.org/0000-0003-1643-7373

Naomi SakaiDepartment of Organic Chemistry, University of Geneva, 1211 Geneva, Switzerland.ORCID https://orcid.org/0000-0002-9460-1944

Stefan MatileDepartment of Organic Chemistry, University of Geneva, 1211 Geneva, Switzerland.ORCID https://orcid.org/0000-0002-8537-8349

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dream to catalyze reactions with externally applied electric fields is so obvious and so promising that it has attracted immense scientific attention. The Diels-Alder (DA) reaction has become the primary reaction to elaborate on this dream, but electric-field catalysis (EFC) of DA reactions under practical organic synthesis conditions remained impossible. The objective of this study was to challenge the emerging principles of scalable EFC in microfluidic capacitors with this holy grail in the field. Functional Helmholtz layers are assembled to translate applied electric fields into effective electric fields that are, according to chronoamperometry, strong enough for the EFC. Yields increase nonlinearly from 0% up to 90% with applied voltage. In chiral cationic Helmholtz layers assembled from polyarginines, benzylated quinines, or ammonium binaphthyls, enantioselectivity up to 31%

Identifiers

PMID42666648

DOI10.1021/acscentsci.6c00852

PMCPMC13523502

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