ArticlePreventive nutrition and food science2026
ε-Viniferin Attenuates LPS-Induced Inflammatory Activation in Canine Macrophages by Regulating NF-κB and MAPK Pathways.
Article in Preventive nutrition and food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic inflammation is a key pathogenic factor contributing to multiple canine diseases, including dermatitis, arthritis, and enteritis. This study investigated the anti-inflammatory effects of ε-viniferin, a resveratrol dimer, in lipopolysaccharide (LPS)-stimulated DH82 canine macrophages. The anti-inflammatory effects of ε-viniferin were evaluated using western blot analysis, quantitative real-time polymerase chain reaction, and enzyme-linked immunosorbent assay. DH82 canine macrophages were pretreated with ε-viniferin (0.2, 0.5, and 1 µM) prior to exposure to LPS (0.1 µg/mL), with no cytotoxic effects observed at these concentrations. ε-Viniferin markedly suppressed the phosphorylation of inhibitor of κB α, nuclear factor-κB (NF-κB), extracellular signal-regulated kinase, and c-Jun N-terminal kinase, indicating concurrent suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways. In addition, ε-viniferin reduced the mRNA expression and secretion of tumor necrosis factor-α (
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