ArticleAdvances in ophthalmology practice and research
Causal effect of gastroesophageal reflux disease on cataracts: A mendelian randomization study.
Article in Advances in ophthalmology practice and research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cataracts, the leading cause of blindness globally, have been linked to genetic variants in regions also implicated in gastroesophageal reflux disease (GERD), suggesting potential pleiotropic effects. While observational studies have hinted at a possible association, the direction and causality of this link remain unclear. To date, no studies have systematically evaluated whether GERD causally contributes to cataract development. Methods: We applied univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) to evaluate the causal effect of GERD on cataracts, using publicly available GWAS summary data from European-ancestry populations, including the GWAS Catalog and the FinnGen consortium. Genetic instruments for GERD were selected from a GWAS meta-analysis involving 602604 individuals, using genome-wide significance ( Results: UVMR analysis showed a significant association between GERD and increased cataract risk (OR: 1.13, Conclusions: This MR study provides genetic evidence supporting a causal effect of GERD on cataract risk. Furthermore, coronary heart disease and diabetes were found to partially mediate this relationship. These findings highlight the potential importance of managing systemic comorbidities in patients with GERD as a supportive strategy to reduce the risk of cataract development and warrant further research into underlying mechanisms.
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