Evidence map›Paper›PMID 42666521›Full record

ArticleNeurobiology of stress2026

Glucocorticoid receptor gene (

June-Ho Seo, Shin Tae Kim, Chun Il Park, Sumoa Jeon, Jee In Kang, Se Joo Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

June-Ho SeoDepartment of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Shin Tae KimDepartment of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea.
Chun Il ParkDepartment of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea.
Sumoa JeonLaboratory for Psychiatric Genetics, Neuroimaging, and Psychoneuroendoimmunology, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Jee In KangDepartment of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea.
Se Joo KimDepartment of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been implicated in obsessive-compulsive disorder (OCD), but epigenetic changes in HPA axis-related genes remain poorly understood. We investigated whether DNA methylation of the glucocorticoid receptor gene ( Methods: A total of 275 patients with OCD and 200 healthy controls (aged 19-40 years) were recruited. DNA methylation at three CpG sites within Results: Compared to healthy controls, DNA methylation at Conclusion: These findings suggest that epigenetic alterations of

Indexed as

DNA methylationGlucocorticoid receptor gene NR3C1Hypothalamo-pituitary-adrenal axisObsessive-compulsive disorderStress resilience

Identifiers

PMID42666521
PMCPMC13522244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.