Evidence map›Paper›PMID 42666492›Full record

ArticleFrontiers in cellular and infection microbiology2026

A pleuromutilin-ciprofloxacin hybrid exhibits potent activity against

Guiyu Zhou, Feike Zhao, Xirui Jia, Xiaoyu Wang, Cunchun Dai, Liangzhu Chen, Binghu Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guiyu ZhouCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
Feike ZhaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
Xirui JiaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
Xiaoyu WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
Cunchun DaiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
Liangzhu ChenGuangdong Wenshi Dahuanong Biotechnology Co, Ltd, Yunfu, Guangdong, China.
Binghu FangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence and dissemination of antimicrobial resistance in Methods: The antibacterial efficacy of PHC was assessed through time-kill kinetics and a murine infection model. Molecular docking was conducted to predict the interactions between PHC and its potential molecular targets, and RT-qPCR analysis was performed to evaluate the effects of PHC on genes associated with DNA replication, ribosomal function, oxidative stress, and energy metabolism in Results: PHC exhibited potent antibacterial activity against Conclusion: PHC exhibits potent antibacterial activity against

Indexed as

Anti-Bacterial AgentsCiprofloxacinDiterpenesStreptococcus suisAdenosine TriphosphateAnimalsBiofilmsDisease Models, AnimalMiceMicrobial Sensitivity TestsMolecular Docking SimulationPleuromutilinsPolycyclic CompoundsReactive Oxygen SpeciesStreptococcal InfectionsAdenosine TriphosphateAnti-Bacterial AgentsCiprofloxacinDiterpenesPleuromutilinsPolycyclic CompoundsReactive Oxygen Speciesantibacterial mechanismantimicrobial candidateantimicrobial resistancehybrid antibacterial agentStreptococcus suis

Identifiers

PMID42666492
PMCPMC13522908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.