Evidence map›Paper›PMID 42666486›Full record

ReviewStem cells international2026

Stromal Vascular Fraction Gel for Osteoarthritis: Mechanisms and Therapeutic Benefits.

Runze Zhang, Yuanhang Yang, Wanli Gao, Xing Lei, Xin Yin, Wei Zhang, Ling Zhang, Yunqi Zhang, Maohua Chen, Junjun Yang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Runze ZhangOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.
Yuanhang YangSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore, ntu.edu.sg.
Wanli GaoOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.
Xing LeiOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.ORCID https://orcid.org/0000-0002-5139-1465
Xin YinOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.
Wei ZhangOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.
Ling ZhangOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.
Yunqi ZhangOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.
Maohua ChenCollege of Artificial Intelligence Medicine, Chongqing Medical University, Chongqing, China, cqmu.edu.cn.ORCID https://orcid.org/0009-0000-3007-4105
Junjun YangOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.
Lisheng WuOrthopedic Medical Center, Linyi People's Hospital, Shandong Second Medical University, Linyi, Shandong, China, ly120.cn.

Funding

HSRD VA I01 HX000156
6 · The paper itself

Abstract

Osteoarthritis (OA), a prevalent degenerative joint disorder, is suboptimally managed by existing treatments owing to adverse effects, limited therapeutic efficacy, and the inability to achieve genuine cartilage repair. Adipose-derived stromal vascular fraction (SVF)-gel, which is abundant in stem cells and bioactive factors, has an autologous origin and favorable immunocompatibility and exhibits favorable safety and efficacy in facilitating cartilage regeneration and repair. Building upon prior research, this review discusses the clinical efficacy and potential of SVF-gel, while also recognizing challenges such as the standardization of preparation procedures and dosage optimization. Future research ought to concentrate on integrating advanced technologies, including gene editing, artificial intelligence (AI), and nanomaterials, to drive its development towards more precise and personalized therapeutic approaches.

Indexed as

osteoarthritisprecision therapyregenerative medicinestromal vascular fraction gel

Identifiers

PMID42666486
PMCPMC13522831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.