Evidence map›Paper›PMID 42666442›Full record

ArticleFood science & nutrition2026

Phytochemical Profiling and Antibacterial Activity of Moroccan Monofloral Honeys Against Multidrug-Resistant Uropathogens: In Vitro, ADMET, Molecular Docking, and Molecular Dynamics Approaches.

Mourad Chikhaoui, Aziz Galman, Ahmed Chetoui, Oussama Khibech, Mohamed Reda Kachmar, Toufik Bouddine, Mohamed Bouhrim, Fahd A Nasr, Mohammed Al-Zharani, Ashraf Ahmed Qurtam and 2 more

Abstract read
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Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mourad ChikhaouiEcology and Environment Laboratory, Faculty of Sciences Ben M'sik Hassan II University Casablanca Morocco.ORCID https://orcid.org/0009-0001-1782-8205
Aziz GalmanHigher Institute of Nursing Professions and Health Techniques Beni-Mellal Morocco.ORCID https://orcid.org/0009-0004-1580-7488
Ahmed ChetouiBiological Engineering Laboratory, Faculty of Sciences, and Techniques Sultan Moulay Slimane University Beni-Mellal Morocco.ORCID https://orcid.org/0000-0002-7876-8285
Oussama KhibechApplied and Environmental Chemistry Laboratory, Department of Chemistry, Faculty of Sciences Mohammed I University Oujda Morocco.ORCID https://orcid.org/0009-0007-9407-7576
Mohamed Reda KachmarHigher Institute of Nursing Professions and Health Techniques Beni-Mellal Morocco.ORCID https://orcid.org/0000-0001-8191-1129
Toufik BouddineBioactive and Environmental Health Laboratory, Faculty of Sciences Moulay Ismail University Meknes Morocco.ORCID https://orcid.org/0000-0002-0915-1257
Mohamed BouhrimLaboratoires TBC, Laboratory of Pharmacology, Pharmacokinetics, and Clinical Pharmacy Faculty of Pharmaceutical and Biological Sciences Lille France.ORCID https://orcid.org/0000-0001-9944-811X
Fahd A NasrBiology Department, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia.ORCID https://orcid.org/0000-0002-6496-7822
Mohammed Al-ZharaniBiology Department, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia.ORCID https://orcid.org/0000-0002-0810-4803
Ashraf Ahmed QurtamBiology Department, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia.
Rachid LotfiHigher Institute of Nursing Professions and Health Techniques Beni-Mellal Morocco.ORCID https://orcid.org/0009-0004-1770-2698
Houda El HajjoujiEcology and Environment Laboratory, Faculty of Sciences Ben M'sik Hassan II University Casablanca Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary tract infections represent a significant public health issue exacerbated by bacterial antibiotic resistance. Honey, due to its phenolic compounds, offers a promising natural alternative. This study explores the phenolic profile of monofloral honeys from the Beni Mellal-Khenifra region and their antibacterial activity against multidrug-resistant strains. Four monofloral honeys from Beni Mellal-Khenifra were analyzed for their phenolic composition and evaluated for antibacterial activity against multidrug-resistant uropathogenic bacteria. Computational studies were also performed to explore the potential mechanisms of action of the identified compounds. HPLC-UV detection identified distinct phenolic profiles in four monofloral honeys. Carob honey showed the highest diversity, with eight compounds identified, notably myricetin (63.99 μg/mg), trans-ferulic acid (33.99 μg/mg), gallic acid (21.02 μg/mg), naringin (17.95 μg/mg), catechin (3.66 μg/mg), and trans-cinnamic acid (2.75 μg/mg). Euphorbia honey was rich in hydroxycinnamic acids, especially caffeic acid (285.35 μg/mg), p-coumaric acid (190.93 μg/mg), and trans-ferulic acid (125.37 μg/mg). Anise honey contained high levels of naringin (669.84 μg/mg), along with myricetin (90.08 μg/mg) and 3-hydroxybenzoic acid (76.59 μg/mg). In contrast, citrus honey exhibited the lowest polyphenolic content, with only gallic acid (0.21 μg/mg) and catechin (2.69 μg/mg) detected. The honey samples exhibited notable antibacterial activity against multidrug-resistant uropathogenic bacteria, including

Indexed as

antibacterial activitycomputational biologymonofloral honeyphenolic compounds

Identifiers

PMID42666442
PMCPMC13522720

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.