ArticleCureus2026
Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens Causing Central Line-Associated Bloodstream Infections in Adult Intensive Care Unit Patients at a Tertiary Care Hospital.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCentral line-associated bloodstream infections (CLABSIs) are important device-associated infections among critically ill patients. The causative organisms and their antimicrobial susceptibility patterns vary between institutions. However, institution-specific data regarding bacterial CLABSIs among adult intensive care unit (ICU) patients in central India remain limited. This study evaluated the occurrence, bacterial profile, and antimicrobial susceptibility patterns of CLABSIs among clinically suspected adult ICU patients with central venous catheters (CVCs). MATERIALS AND
methodsA prospective observational study was conducted in the adult ICU of Index Medical College Hospital and Research Centre, Indore, India, from January 2024 to December 2025. A total of 245 consecutively enrolled patients aged >18 years with a CVC in place for >48 hours and clinical suspicion of having a bloodstream infection were included. Blood specimens were obtained aseptically from peripheral veins and CVCs. Blood-culture bottles were processed using the BacT/ALERT 3D automated system, and positive cultures were subcultured onto blood agar and MacConkey agar. Bacterial isolates were presumptively identified using standard biochemical tests and further identified to the species level using the VITEK 2 Compact system. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disc-diffusion method, while colistin susceptibility was determined by broth microdilution, and vancomycin minimum inhibitory concentration was determined by VITEK 2. Results were interpreted according to the CLSI 2024.
resultsAmong the 245 ICU patients included in the study, 35 (14.29%) were confirmed to have CLABSI, whereas 210 (85.71%) were CLABSI-negative. The overall CLABSI rate was 13.70 episodes per 1,000 catheter-days. Among positive cases, 23 (65.7%) were male and 12 (34.3%) were female. Most cases occurred in patients aged 61-80 years, and the Cardiac Care Unit had the highest positivity rate. Gram-negative bacilli (GNB) accounted for 26 (74.3%) isolates and Gram-positive cocci (GPC) accounted for nine (25.7%). Among GNB,
conclusionsCLABSIs continue to be notable healthcare-associated infections among ICU patients with CVCs, affecting 35 (14.29%) of the 245 patients included in the study. The prevalence of multidrug-resistant Gram-negative bacteria, particularly
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