ArticleFrontiers in microbiology2026
HPV vaccination associates with
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Human papillomavirus (HPV) vaccination provides high-level protection against cervical cancer through type-specific antibodies, although breakthrough and persistent high-risk HPV (hrHPV) infections may still occur in some vaccinated women. In addition to neutralizing antibodies, vaccination elicits other immune mechanisms that may influence viral persistence and disease progression. Because mucosal immunity is closely linked to the vaginal microbiota, microbial composition may also play an important role in HPV susceptibility, with Method: We analyzed vaginal samples via shotgun metagenomic sequencing from a cross-sectional study of 59 pre-menopausal women (<50 years) with confirmed cervical lesions (HPV-unvaccinated Results: Alpha diversity (Shannon and Inverse Simpson indices) did not differ significantly by vaccination status, suggesting within-sample microbial diversity between the groups, but Bray-Curtis-based PERMANOVA indicated a statistically significant difference in overall community composition between groups ( Conclusion: These findings support the hypothesis that HPV vaccination status is associated with
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