Evidence map›Paper›PMID 42666328›Full record

ArticleFrontiers in immunology2026

Type 17 T-cell subset divergence in hidradenitis suppurativa versus psoriasis: a comparative single-cell transcriptomic analysis.

Nayoung Park, Jongeun Lee, Dayeon Kim, Darshna Rambhia, Jaebum Kim, Wei Zhou, Junyue Cao, James G Krueger, Younhee Ko, Jaehwan Kim

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nayoung Park *Department of Biomedical Science and Engineering, Konkuk University, Seoul, Republic of Korea.
Jongeun Lee *Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, United States.
Dayeon KimDivision of Biomedical Engineering, Hankuk University of Foreign Studies, Kyoungki-do, Republic of Korea.
Darshna RambhiaLaboratory for Investigative Dermatology, The Rockefeller University, New York, NY, United States.
Jaebum KimDepartment of Biomedical Science and Engineering, Konkuk University, Seoul, Republic of Korea.
Wei ZhouLaboratory of Single-cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, United States.
Junyue CaoLaboratory of Single-cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, United States.
James G KruegerLaboratory for Investigative Dermatology, The Rockefeller University, New York, NY, United States.
Younhee KoDivision of Biomedical Engineering, Hankuk University of Foreign Studies, Kyoungki-do, Republic of Korea.
Jaehwan KimLaboratory for Investigative Dermatology, The Rockefeller University, New York, NY, United States.

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
A clinical trial for psoriasis with novel single-cell genomic techniques to understand regulatory immunity behind long-term disease remission off drug induced by short-term IL-23 inhibitionK23AR080043 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Jaehwan Kim · 2022 to 2026
$846k
NCATS NIH HHS UL1 TR001866NIAMS NIH HHS K23 AR080043
6 · The paper itself

Abstract

Background: IL-17-producing Type 17 T (T17) cells are central drivers of inflammation in both psoriasis and hidradenitis suppurativa (HS), as evidenced by the clinical efficacy of IL-17-targeting therapies. However, therapeutic responses differ substantially between diseases, raising the possibility that the composition and regulation of T17 states are disease context dependent. Objective: To define disease-specific T17 subset composition and regulatory T-cell (Treg) transcriptional programs in psoriasis and HS at single-cell resolution, and to generate hypothesis framework regarding their potential relationship to differential therapeutic responses. Methods: We performed integrated single-cell RNA sequencing (scRNA-seq) analysis of lesional skin from psoriasis (n=20), HS (n=8), atopic dermatitis (AD; n=4), and healthy controls (n=19). T17 subsets were defined based on Results: Psoriasis lesions were enriched in Conclusion: These findings reveal a marked divergence in type 17 immunity between psoriasis and HS. HS is characterized by expansion of

Indexed as

Hidradenitis SuppurativaPsoriasisTh17 CellsT-Lymphocyte SubsetsTranscriptomeAdultFemaleGene Expression ProfilingHumansInterleukin-17MaleMiddle AgedSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisT-Lymphocytes, RegulatoryInterleukin-17hidradenitis suppurativapsoriasisregulatory T-cellssingle-cell RNA sequencingtype 17 T-cells

Identifiers

PMID42666328
PMCPMC13522199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.