ArticleFrontiers in pharmacology2026
Anticancer potential of
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Plant-derived polyphenols, including catechins, have been extensively studied for their anticancer properties for years. However, complex plant extracts may exhibit enhanced activity compared to isolated compounds owing to synergistic/additive phytochemical interactions. To date, the anticancer potential of extracts from Purpose: This study aimed to evaluate the anticancer activity of Methods: Methanolic root extracts and pure catechins were tested against five human cancer cell lines (A549, MDA-MB-231, Ramos, Namalwa, Raji) and human fibroblasts (BJ) as a control using the MTT assay. The mode of cell death was assessed by flow cytometry and Annexin V-FITC/PI staining. Results: The root extract induced a reduction in cancer cell viability comparable to that observed for isolated catechins, despite containing substantially lower concentrations of these compounds. This effect was most pronounced in lymphoma cells, which showed the highest sensitivity to extract treatment. Flow cytometric analysis indicated that the extract predominantly triggered apoptotic cell death. Conclusion: Despite its low catechin concentration, the extract from roots of
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