Evidence map›Paper›PMID 42666236›Full record

ArticleFrontiers in endocrinology2026

Complex landscape of somatic copy number alterations in head and neck paragangliomas.

Vladislav S Pavlov, Maria S Fedorova, Turpal-Ali S M Elnukaev, Dmitry V Kalinin, Elena A Pudova, Irina V Katunina, Zulfiya G Guvatova, Anastasia A Kobelyatskaya, Andrey D Kaprin, Anna V Kudryavtseva and 1 more

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Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Vladislav S PavlovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Maria S FedorovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Turpal-Ali S M ElnukaevEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Dmitry V KalininVishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia.
Elena A PudovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Irina V KatuninaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Zulfiya G GuvatovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasia A KobelyatskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Andrey D KaprinNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia.
Anna V KudryavtsevaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasiya V SnezhkinaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Copy number alterations (CNAs) drive cancer by amplifying oncogenes and deleting tumor suppressor genes. Although CNA patterns are well-studied in common cancers, they remain poorly characterized in rare tumors. Methods: In this study, we employed an allele-specific copy number analysis using ASCAT on 25 head and neck paragangliomas (HNPGLs) with high tumor cell purity (≥70%) and available clinicopathologic and mutation data. Results: The majority of HNPGLs exhibited a near-diploid state. The recurrent somatic CNAs were predominantly hemizygous deletions, frequently affecting chromosomal regions 7q11, 1p36, 1p34, and 1p21.1-1p13.2, and involving key tumor suppressor genes associated with paragangliomas/pheochromocytomas (PPGLs), including Conclusion: Collectively, our study reveals a complex landscape of somatic CNAs in HNPGLs. The presence of recurrent alterations in hotspot genomic loci and PPGLs-associated genes suggests that genomic instability may be a significant contributing factor to tumor development and progression.

Indexed as

DNA Copy Number VariationsHead and Neck NeoplasmsParagangliomaFemaleHumansMutationallele-specific analysiscopy number alterationsgenomic instabilityhead and neck paragangliomasoncogenestumor suppressor genes

Identifiers

PMID42666236
PMCPMC13521833

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