ArticleFrontiers in public health2026
Geriatric syndromes and intrinsic capacity in older adults with coronary heart disease: a cross-sectional study in China.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Geriatric syndromes (GS) are highly prevalent among community-dwelling older adults with self-reported physician-diagnosed coronary heart disease (CHD), but their association with intrinsic capacity (IC) remains poorly characterized. Methods: We analyzed cross-sectional data from 5,835 community-dwelling Chinese older adults with self-reported physician-diagnosed CHD (mean age 74.4 years; 65.8% women). GS burden (0 to ≥4) and specific comorbidities were examined against overall IC impairment and its five domains (locomotion, cognition, sensory, vitality, psychological). Adjusted prevalence ratios (PR) were estimated using multivariable modified Poisson regression models. Sensitivity analyses accounted for frailty, disability, and conceptual overlap between exposure and outcome domains, and the exclusion of severe end-stage deficits. Results: Overall, 69.6% of participants had ≥1 GS. IC impairment prevalence increased progressively with GS burden, from 35.6% (0 GS) to 84.7% (≥4 GS). Compared to those with 0 GS, participants with ≥4 GS had a substantially higher prevalence of overall IC impairment (PR = 2.00; 95% CI: 1.76-2.27), locomotion difficulties (PR = 6.52), and psychological problems (PR = 6.68; all Conclusion: In community-dwelling older adults with self-reported physician-diagnosed CHD, a higher GS burden is strongly and independently associated with IC impairment, reflecting a functional continuum from early capacity declines to advanced physical vulnerability. This graded relationship persists even when accounting for physical vulnerability, highlighting the critical value of identifying high-risk GS clusters to proactively manage IC.
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