ArticleFrontiers in oncology2026
Correlation between atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion and cervical lesions: a retrospective analysis of opportunistic and organized cervical screening populations.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: We compared Liquid-Based Cytologic Test (LCT) results diagnosed as atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H) with high-risk human papillomavirus (hrHPV) infection status and histopathological findings across two cervical screening groups. Additionally, we analyzed the clinical correlation of ASC-H with cervical lesions. Methods: This retrospective analysis included 171,688 cases. LCT specimens were divided into two groups: 31,100 from patients who underwent organized cervical screening with artificial intelligence(AI)-assisted interpretation; and 140,588 from patients who underwent opportunistic screening interpreted manually. Of the 663 cases diagnosed with ASC-H, 387 underwent both HPV testing and subsequent histopathological examination. HPV detection methods included 23-type HPV genotyping, and the Cobas 4800 assay which identifies HPV16/18 plus 12 other hrHPV subtypes. Results: The overall prevalence of ASC-H was 0.39%. Among 387 paired cases of ASC-H, the total HPV infection rate reached 84.00%, with hrHPV accounting for 97.82% of cases. Women aged <50 years exhibited more single HPV genotype infections and a significantly higher positivity rate for hrHPV than those aged ≥50 years ( Conclusion: ASC-H indicates a significant risk of HSIL+, particularly in younger women, regardless of interpretation (AI-assisted or manual). These patients require timely evaluation and suitable treatment, as well as careful follow-up to minimize the risk of missed diagnoses of precancerous lesions and early cervical cancer.
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