Evidence map›Paper›PMID 42666166›Full record

ArticleFrontiers in oncology2026

Interpretation of p53 immunohistochemical stain of TP53-mutated myeloid neoplasms.

Nawroz Barwari, William Patrick Morrow, Joni K Evans, Nancy Rosenthal, Michael W Beaty, Eric Hsi, Giovanni Insuasti-Beltran, Danielle L V Maracaja

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nawroz BarwariDepartment of Pathology, Wake Forest University School of Medicine/Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.
William Patrick MorrowDepartment of Pathology, Wake Forest University School of Medicine/Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.
Joni K EvansDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Nancy RosenthalDepartment of Pathology, Wake Forest University School of Medicine/Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.
Michael W BeatyDepartment of Pathology, Wake Forest University School of Medicine/Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.
Eric HsiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Giovanni Insuasti-BeltranDepartment of Pathology, Wake Forest University School of Medicine/Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.
Danielle L V MaracajaDepartment of Pathology, Wake Forest University School of Medicine/Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Fifty-three bone marrow (BM) specimens previously diagnosed as myeloid neoplasms or nonneoplastic BM specimens with available concurrent Results: The intraclass correlation was excellent for OSP (0.927) and good for DCP (0.848). For OSP, a cutoff of 30% resulted in sensitivity of 83.3%, specificity of 89.7%, PPV of 87.0%, and NPV of 86.7%. For DCP, a cutoff of 10% achieved sensitivity of 87.5%, specificity of 96.6%, PPV of 95.4%, and NPV of 90.3%. Additionally, DCP significantly correlated with the VAF of Conclusion: High inter-rater reliability for OSP and DCP supports integrating p53 IHC into bone marrow evaluations for rapid

Indexed as

diagnostic accuracyinterobserver agreement assessmentp53 immunohistochemistry (p53 IHC)p53 protein expressionTP53-mutated myeloid neoplasmsTP53 mutation and expression

Identifiers

PMID42666166
PMCPMC13521820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.