Evidence map›Paper›PMID 42666071›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Defect-Engineered BiO

Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huimin Tian *Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Shen Zhang *Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Bolin Wu *Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.ORCID https://orcid.org/0009-0002-8590-7391
Yichi ChenDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.ORCID https://orcid.org/0000-0002-1976-9595
Haitao ShangDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Haoyan TanDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.ORCID https://orcid.org/0000-0002-3412-5982
Chunyue WangDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Weichen XuDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Huixiong XuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-8699-854X
Haohao YinDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-5404-7336
Wen ChengDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.ORCID https://orcid.org/0000-0003-4294-9698

Funding

China Postdoctoral Science Foundation 2023TQ0073Climbing Program of Harbin Medical University Cancer Hospital PDYS2024-15Joint Fund Cultivation Project of Heilongjiang Provincial Natural Science Foundation PL2025H195Ministry of Science and Technology of China 2023YFC2414202Ministry of Science and Technology of China 2023YFC2414203Ministry of Science and Technology of China 2023YFC2414204National Natural Science Foundation of China 82302206National Natural Science Foundation of China 82430064National Natural Science Foundation of China 82572242Scientific Research and Development Fund of Zhongshan Hospital of Fudan University 2022ZSQD07Shanghai Sailing Program 23YF1441600
6 · The paper itself

Abstract

Immune checkpoint blockade for hepatocellular carcinoma (HCC) is frequently limited by the extracellular matrix (ECM). Through transcriptomic profiling, we identify that acquired anti-PD-1 resistance in HCC models is closely associated with prominent Fibronectin 1 (Fn1) upregulation within the tumor microenvironment. To address these interconnected physical and biological barriers, we developed an ultrasound-responsive nanoplatform utilizing oxygen-defect-abundant 2D BiO

Indexed as

extracellular matrixfibronectin 1hepatocellular carcinomaimmunotherapyultrasound

Identifiers

PMID42666071
PMCPMC13525413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.