Evidence map›Paper›PMID 42666013›Full record

Trial reportActa physiologica (Oxford, England)2026

Innovative Dose-Response Assessment of the Metaboreflex With Indirect Control of Intramuscular Metabolic Perturbation in Humans.

Nabil Kouzkouz, Joris Mallard, Elyse Hucteau, Roland Schott, Xavier Pivot, Guillaume P Ducrocq, Thomas J Hureau

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06775119 (Feasibility Study of a Neuromuscular Fatigue Test and Associated Hemodynamic Responses), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06775119 nacompletednot on this map

Feasibility Study of a Neuromuscular Fatigue Test and Associated Hemodynamic Responses: Application in Healthy Volunteers for Use in Patients with Chemotherapy-treated Breast Cancer

TypeinterventionalSponsorInstitut de cancérologie Strasbourg EuropeRan2024 to 2025Enrolled30ConditionsFatigue, Muscle, HeartArmsTest of neuromuscular fatigue and associated hemodynamic responses
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nabil KouzkouzMitochondria, Oxidative Stress, and Muscle Plasticity Laboratory (UR 3072), Biomedicine Research Center of Strasbourg (CRBS), University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0009-0006-0185-9257
Joris MallardMitochondria, Oxidative Stress, and Muscle Plasticity Laboratory (UR 3072), Biomedicine Research Center of Strasbourg (CRBS), University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0009-0009-0890-3136
Elyse HucteauMitochondria, Oxidative Stress, and Muscle Plasticity Laboratory (UR 3072), Biomedicine Research Center of Strasbourg (CRBS), University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-9236-6514
Roland SchottExercise Physiology Laboratory, Institut Strauss, Strasbourg, France.
Xavier PivotExercise Physiology Laboratory, Institut Strauss, Strasbourg, France.
Guillaume P DucrocqMitochondria, Oxidative Stress, and Muscle Plasticity Laboratory (UR 3072), Biomedicine Research Center of Strasbourg (CRBS), University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0003-3531-4678
Thomas J HureauMitochondria, Oxidative Stress, and Muscle Plasticity Laboratory (UR 3072), Biomedicine Research Center of Strasbourg (CRBS), University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-6993-5723

Funding

Institut Public de Cancérologie Strauss EuropeUniversity of Strasbourg ANR-10-IDEX-0002-02
6 · The paper itself

Abstract

aimWe aimed to evaluate an innovative dose-response approach to assess the metaboreflex with control of intramuscular metabolic perturbation (concept of metaboreflex gain). We also investigated potential sex differences in the metaboreflex using this new approach.

methodsThirty participants (15 females) completed one familiarization and two experimental visits to evaluate the method and assess its reproducibility. Each visit involved four consecutive bouts of sustained isometric knee extension at 20% of maximal voluntary force interspersed with 2 min of post-exercise circulatory occlusion (PECO). Intramuscular metabolic perturbation was quantified indirectly via changes in quadriceps twitch force evoked by electrical stimulation of the femoral nerve (∆Q

resultsWe found a gradual increase in ∆MAP (p < 0.0001) that was linearly correlated with the gradual decrease in ∆Q

conclusionThis study highlights the critical need for using a dose-response relationship while accounting for neuromuscular fatigue as a proxy for the metabolic stimulus when assessing the muscle metaboreflex in humans.

trial registrationClinical trials registration number: NCT06775119.

Indexed as

ExerciseMuscle, SkeletalQuadriceps MuscleReflexAdultElectric StimulationFemaleFemoral NerveHumansIsometric ContractionMaleYoung Adultexercise pressor reflexGroup III/IV muscle afferentsmetaboreflexmuscle fatiguepost‐exercise circulatory occlusionsex differences

Identifiers

PMID42666013
PMCPMC13525395

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.