ArticleOncoimmunology2026
Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.
María Cruz Cobo, Laure Garnier, Marion Mandavit, Maral Azam, Isabelle Dentand Quadri, Julien Angelillo, Dale Brighouse, Mathilde Bausart, Valérie Dutoit, Achille Schild and 5 more
Abstract read
In one paragraphArticle in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
María Cruz CoboGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.
Laure GarnierGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-4006-5741 Marion MandavitGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.
Maral AzamGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.
Isabelle Dentand QuadriGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.
Julien AngelilloGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.ORCID 0000-0003-2591-651X Dale BrighouseGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.
Mathilde BausartGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-9117-8338 Valérie DutoitBrain Tumor and Immune Cell Engineering Laboratory, Translational Research Center in Oncohaematology, Faculty of Medicine, Department of Medicine, University of Geneva, Geneva, Switzerland ; and Swiss Cancer Center Léman (SCCL), Switzerland.ORCID 0000-0002-3469-4237 Achille SchildInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Valeria M OlivaGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.ORCID 0009-0004-1529-9778 Martin LochnerInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0003-4930-1886 Bénédicte ManouryInstitut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, Faculté de Médecine Necker, Université Paris Cité, Paris, France.ORCID 0000-0001-7784-3389 Stéphanie HuguesGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-1031-5909 Paula Nunes-HaslerGeneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-4598-685X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
summaryCruz Cobo et al. identify small molecules that reprogram dendritic cells toward an immuno-stimulating secretory phenotype, revealing endoplasmic reticulum calcium signaling as a druggable axis to boost vaccine-based and T cell-mediated cancer immunotherapies. The study links broad changes in calcium-induced secretion to improved immune activation and therapeutic potency.
Indexed as
Calcium SignalingCancer VaccinesDendritic CellsMelanomaAnimalsCalciumEndoplasmic ReticulumHumansImmunotherapyCalciumCancer VaccinesAntigen presentationcell-based therapyDC vaccineimmunotherapymelanomastore-operated calcium entry
Identifiers
PMID42666008
PMCPMC13531994
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