Evidence map›Paper›PMID 42665974›Full record

Trial reportPhysiological reports2026

Immunological effects of supervised exercise in long COVID in adults: A secondary analysis of a randomized crossover trial.

Nora García-Alonso, Mikel Izquierdo, Hugo Arasanz, Robinson Ramírez-Vélez

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nora García-AlonsoInstituto de Investigación Sanitaria de Navarra (IdiSNA), Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Pamplona, Spain.ORCID https://orcid.org/0000-0002-8353-7430
Mikel IzquierdoInstituto de Investigación Sanitaria de Navarra (IdiSNA), Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Pamplona, Spain.ORCID https://orcid.org/0000-0002-1506-4272
Hugo ArasanzMedical Oncology Department, Hospital Universitario de Navarra, Pamplona, Spain.ORCID https://orcid.org/0000-0001-6838-6702
Robinson Ramírez-VélezInstituto de Investigación Sanitaria de Navarra (IdiSNA), Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Pamplona, Spain.ORCID https://orcid.org/0000-0003-3075-6960

Funding

MEC | Spanish National Plan for Scientific and Technical Research and Innovation (Plan Estatal de Investigación Científica y Técnica y de Innovación) PID2020-113098RB-I00
6 · The paper itself

Abstract

Long COVID (post-acute sequelae of SARS-CoV-2 infection) affects approximately 5%-30% of survivors and is characterized by persistent fatigue, dyspnea, exercise intolerance, and cognitive impairment. We evaluated the immunological effects of supervised exercise in adults with long COVID. In this pre-specified exploratory substudy of the EXER-COVID randomized 2 × 2 crossover trial, participants completed a 6-week supervised exercise program (twice weekly) or usual care before crossing over after a 3-5 day washout. Plasma cytokines (IL-1β, IL-6, IL-10, TNF-α, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, and IP-10/CXCL10) were measured by multiplex immunoassay. Immunophenotyping included 20 CD4

Indexed as

Exercise TherapyPost-Acute COVID-19 SyndromeAdultAgedCross-Over StudiesCytokinesFemaleHumansMaleMiddle AgedSARS-CoV-2Cytokinescytokinesexercise trainingimmunophenotypinglong COVIDT lymphocytes

Identifiers

PMID42665974
PMCPMC13525194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.