Evidence map›Paper›PMID 42665973›Full record

ArticleMolecular plant pathology2026

Transcriptional and Functional Insights Into the All-Stage Resistance Gene GmRmd1-Mediated Regulation of Resistance to Powdery Mildew in Soybean.

Guoqiang Liu, Chen Ling, Tingting Xu, Xuehui Zhang, Jiacan Jiang, Xiaomin Xu, Lu Li, Jiajian Zhang, Bing Hu, Mengshi Liu and 2 more

Abstract read
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In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Guoqiang LiuGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.ORCID https://orcid.org/0009-0009-9835-5670
Chen LingGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Tingting XuGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Xuehui ZhangGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Jiacan JiangGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.ORCID https://orcid.org/0009-0008-4570-3873
Xiaomin XuGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Lu LiGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Jiajian ZhangGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Bing HuGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Mengshi LiuGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.
Yunxin HeYuelushan Laboratory/Institute of Cotton and Sericulture, Hunan Academy of Agricultural Sciences, Changsha, China.
Cunyi YangGuangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, China.

Funding

Guangdong Laboratory of Lingnan Modern Agriculturethe National Natural Science Foundation of China 32172061the Open Competition Program of Top Ten Critical Priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province 2022SDZG05Yuelushan Laboratory Talent Program 2025RC2022
6 · The paper itself

Abstract

Powdery mildew disease (PMD), caused by Microsphaera diffusa, is a devastating soybean foliar disease. This study identified GmRmd1 as a candidate in Guangxi landrace MSRF (all-stage resistance to PMD) and validated it as a positive PMD resistance regulator. Hypersensitive response (HR) assays confirmed its Toll interleukin-1 receptor (TIR), nucleotide-binding site (NBS) and basic secretory protein (BSP) domains are critical for immune responses. GmRmd1 was induced by M. diffusa, and its expression was inhibited by GmWRKY27 and GmERF138 specifically binding to the W-box and GCC-box elements of the GmRmd1 promoter, respectively. RNA-Seq revealed that chromosome 16 (chr16) resistance cluster genes (Glyma.16G214100, Glyma.16G214200, Glyma.16G215100 and Glyma.16G215800) showed GmRmd1-related expression patterns. Yeast two-hybrid, bimolecular fluorescence complementation and luciferase assays demonstrated GmRmd1 interacts not only with itself, but also with GmRmd2 (Glyma.16G215100), GmRmd3 (Glyma.16G214900) and GmRnl1 (NLR cofactor). In addition, mutants of GmRmd3 and GmRnl1 are more susceptible to M. diffusa. Notably, GmRmd1 enhances the resistance of PMD by interacting with GmPER1 (lignin synthesis-related) and increasing the synthesis of lignin. Genomic analysis indicated that the number of soybean accessions carrying the GmRmd1 locus gradually decreases from north to south and from west to east in China. Taken together, GmRmd1 forms functional protein complexes with GmRmd2, GmRmd3, and GmRnl1 to regulate lignin biosynthesis and thereby modulate disease resistance. These insights provide novel perspectives into the molecular mechanisms of GmRmd1-mediated resistance to soybean PMD.

Indexed as

AscomycotaDisease ResistanceGenes, PlantGlycine maxPlant DiseasesPlant ProteinsTranscription, GeneticGene Expression Regulation, PlantPromoter Regions, GeneticProtein BindingPlant Proteinsgene mappingGmRmd1ligninPMDprotein interactionRNA‐Seq

Identifiers

PMID42665973
PMCPMC13525195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.