ArticleAngewandte Chemie (International ed. in English)2026
Modular and Stereoselective Synthesis of Cyclobutane β-Amino Alcohols.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cyclobutane β-amino alcohols are valuable structural motifs, yet their development has lagged behind that of five- and six-membered analogs due to limited synthetic accessibility. In this work, we report a general and modular strategy for the synthesis of diversely substituted cyclobutane β-amino alcohols. The electronic structure of 1,2-azaborines is leveraged to achieve regioselective mono- and difunctionalization at all four carbon positions. The installed functionalities are subsequently translated into cyclobutane β-amino alcohol frameworks through a tandem photoisomerization-hydrogenation-oxidation sequence. This strategy provides access to eight distinct substitution patterns with high levels of modularity and diastereoselectivity.
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