Evidence map›Paper›PMID 42665812›Full record

ReviewRespiratory research2026

Alarmins differentially modulate airway contraction and relaxation of human small airways.

Joshua L Kennedy, Dana N Frederick, Reynold A Panettieri, Cynthia J Koziol-White

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua L KennedyArkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR, 72211, USA.
Dana N FrederickArkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR, 72211, USA.
Reynold A PanettieriRutgers Institute for Translational Medicine and Science, Rutgers University, 89 French Street, Suite 4210, New Brunswick, NJ, 08901, USA.
Cynthia J Koziol-WhiteRutgers Institute for Translational Medicine and Science, Rutgers University, 89 French Street, Suite 4210, New Brunswick, NJ, 08901, USA. cjk167@rbhs.rutgers.edu.

Funding

Strategies for biasing and augmenting b2-adrenoceptor signaling and function in ASMP01HL180318 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI RAYMOND B. PENN · 2025 to 2026
$7.1M
An Integrated Host-Microbe Gene Classifier to Predict SARS-CoV-2 and Severe Disease in Children with Respiratory Viral CoinfectionsR01HL173537 · NHLBI · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Joshua Kennedy · 2024 to 2026
$2.0M
Rhinovirus, airway smooth muscle, and mechanisms of irreversible airflow obstructionR01HL166594 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Cynthia Koziol-White · 2023 to 2026
$1.9M
NHLBI NIH HHS P01 HL180318NHLBI NIH HHS R01 HL166594NHLBI NIH HHS R01 HL173537NIH HHS P01HL180318NIH HHS R01HL166594NIH HHS R01HL173537
6 · The paper itself

Abstract

Alarmins, including Thymic Stromal Lymphopoietin (TSLP) and Interleukins 33 and 25 (IL-33 and IL-25), contribute to the pathophysiology of allergic and nonallergic asthma by evoking exacerbations in response to allergens, viruses, and environmental irritants (as reviewed in [1]). Current evidence shows that inhibiting alarmins reduces symptoms and exacerbations in obstructive lung diseases, including asthma [1]. Preclinical work has largely focused on alarmins' role in modulating airway inflammation, but far less is known about how alarmins regulate airway tone (contraction and relaxation). We posit that IL-33, TSLP, and IL-25 exert distinct effects on airway contraction and relaxation in airways from non-diseased subjects and those with asthma.

Indexed as

AlarminsAsthmaBronchoconstrictionMuscle RelaxationAnimalsCytokinesHumansInterleukin-33AlarminsCytokinesInterleukin-33Airway constrictionAirway dilationAlarminsAsthmaBronchodilator

Identifiers

PMID42665812
PMCPMC13523187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.