Trial reportBMC pharmacology & toxicology2026
Pharmacokinetic and bioequivalence study of enteric-coated omeprazole capsule in healthy Chinese subjects under fasting and fed conditions.
Trial report in BMC pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeThis study aimed to evaluate the bioequivalence of a generic enteric-coated omeprazole capsule compared with the reference product (Losec
methodThe fasting study was conducted using a randomized, single-centre, single-dose, two-period, two-sequence crossover design. The fed study was a randomized, single-centre, single-dose, four-period, two-sequence fully replicate crossover design. Healthy subjects were randomized and received either the test or the reference drug under fasting or fed conditions. The plasma concentration of enteric-coated omeprazole capsule at different time points was measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Bioequivalence of the two formulations was evaluated through pharmacokinetic parameters and relative bioavailability.
resultsIn the fasting study, the geometric mean ratios (GMRs) of C
conclusionThe two enteric-coated omeprazole capsules were bioequivalent under both fasting and fed conditions and were well tolerated in healthy subjects.
trial registrationThe trial was registered with the China Centre for Drug Testing and Registration ( http://www.chinadrugtrials.org.cn/index.html , 10/05/2022, CTR20221098 and CTR20220627).
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