Evidence map›Paper›PMID 42665771›Full record

ArticleJournal of thrombosis and thrombolysis2026

Ticagrelor 60 mg vs. 90 mg in elderly ACS patients with vs. without diabetes undergoing percutaneous coronary intervention.

Angelo Laino, Raffaele Piccolo, Mario Enrico Canonico, Marisa Avvedimento, Fiorenzo Simonetti, Roberta Paolillo, Fabrizio Dal Piaz, Bruno Charlier, Alessandra Spinelli, Stefano Cristiano and 7 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04739384 (Platelet Inhibition With Ticagrelor 60 mg Versus Ticagrelor 90 mg Twice Daily in Elderly Patients With Acute Coronary Syndrome), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04739384 phase3completednot on this map

Platelet Inhibition With Ticagrelor 60 mg Versus Ticagrelor 90 mg Twice Daily in Elderly Patients With Acute Coronary Syndrome (ACS)

TypeinterventionalSponsorFederico II UniversityRan2021 to 2022Enrolled50ConditionsAcute Coronary Syndrome, STEMI, NSTEMI, Coronary Artery DiseaseArmsTicagrelor 90mg, Ticagrelor 60 mg
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Angelo LainoDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Raffaele PiccoloDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy. Raffaele.Piccolo@unina.it.ORCID http://orcid.org/0000-0002-3124-9912
Mario Enrico CanonicoDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Marisa AvvedimentoDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Fiorenzo SimonettiDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Roberta PaolilloDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Fabrizio Dal PiazDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.
Bruno CharlierDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.
Alessandra SpinelliDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Stefano CristianoDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Luigi Di SerafinoDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Plinio CirilloDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Giuseppe GargiuloDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Anna FranzoneDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.
Amelia FilippelliDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.
Valeria ContiDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.
Giovanni EspositoDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

No data are available on the pharmacodynamic and pharmacokinetic profile of a low dose of ticagrelor as alternative to its standard dose during the early phase after acute coronary syndrome (ACS) according to diabetic status. We reported a post-hoc analysis of a randomized, crossover trial (NCT04739384) comparing ticagrelor 60 vs. 90 mg in elderly patients with ACS according to the presence or absence of diabetes. The primary endpoint was the pre-dose P2Y

Indexed as

Acute coronary syndromesDiabetesElderlyPlateletsTicagrelor

Identifiers

PMID42665771

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.