Evidence map›Paper›PMID 42665759›Full record

ReviewStem cell reviews and reports2026

Mechanistic Study of m5C Modification in Stem Cell Differentiation and Disease Regulation.

Xiangrong Zhang, Jianqiao Li, Zhifeng Zhang, Xueqian Chen, Jiankai Yang, Wei Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangrong Zhang *Hebei Medical University, 361 Zhongshan East Rd, Shijiazhuang, 050017, China.
Jianqiao Li *Hebei Medical University, 361 Zhongshan East Rd, Shijiazhuang, 050017, China.
Zhifeng ZhangHebei Medical University, 361 Zhongshan East Rd, Shijiazhuang, 050017, China.
Xueqian ChenHebei Medical University, 361 Zhongshan East Rd, Shijiazhuang, 050017, China.
Jiankai YangDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China. jiankaiyang@hebmu.edu.cn.
Wei LiuHebei Medical University, 361 Zhongshan East Rd, Shijiazhuang, 050017, China. liuweihebmu@hebmu.edu.cn.

Funding

Central Guidance for Local Science and Technology Development Fund Projects of Department of Science and Technology of Hebei Province 246Z7743G
6 · The paper itself

Abstract

m5C (5-methylcytosine) modification is a significant epigenetic modification in RNA that has garnered substantial attention in recent years in stem cell biology and disease research. The dynamic regulation of m5C involves methyltransferases, demethylases, and specific binding proteins, which collectively influence RNA stability, translation efficiency, and cellular function. Especially in stem cell differentiation, m5C modification not only affects stem cell self-renewal and differentiation fate but is also closely associated with the onset and progression of various diseases. This review explores the mechanisms of m5C modification in stem cell differentiation and related diseases, highlighting its emerging roles in gene expression regulation and disease pathogenesis. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

DiseaseM5CMethylation ModificationStem Cell Differentiation

Identifiers

PMID42665759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.