Evidence map›Paper›PMID 42665747›Full record

ArticleDigestive diseases and sciences2026

Longitudinal Adherence to Hepatocellular Carcinoma Surveillance and Associated Outcomes Following Ultrasound Liver Imaging Reporting and Data System (US LI-RADS) Implementation.

Stephanie M Kim, Kang Wang, Hailey H Choi, Amy M Shui, Nicholas Finke, Rena K Fox, Mandana Khalili

Abstract read
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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Stephanie M KimDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, USA.
Kang WangDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Hailey H ChoiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Amy M ShuiDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Nicholas FinkeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Rena K FoxDepartment of Medicine, Division of General Internal Medicine, University of California San Francisco, San Francisco, CA, USA.
Mandana KhaliliDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, USA. mandana.khalili@ucsf.edu.ORCID https://orcid.org/0000-0001-9178-9139

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Mentoring Multidisciplinary Patient-Oriented Research in Viral HepatitisK24AA022523 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2013 to 2023
$1.9M
NIAAA NIH HHS K24 AA022523NIDDK NIH HHS P30 DK026743NIH HHS K24AA022523NIH HHS P30DK026743
6 · The paper itself

Abstract

objectivesHepatocellular carcinoma (HCC) surveillance remains suboptimal. We evaluated longitudinal trends in HCC surveillance adherence, its associated factors, and impact on HCC-related outcomes, following US LI-RADS implementation in a safety-net system.

methodsElectronic medical records and radiology database were queried from 6/1/2020 to /31/2021, with follow-up (median 51 months) through 12/31/2024. Multivariable repeated measures logistic regression assessed factors associated with full (vs. partial/none) HCC surveillance adherence. Adherence trends were analyzed using a nonparametric mean cumulative function. Cox proportional hazards models assessed the association between adherence and composite outcomes of HCC or death.

resultsAmong 1083 patients, mean age was 59.3, 44% female, 64% had HBV, and 38% cirrhosis. Hepatology clinic attendance was the strongest factor associated with full adherence (OR 2.61) followed by prior ultrasound, male sex, and older age. Current alcohol use (OR 0.58) and smoking (OR 0.65) were associated with lower adherence. The rate of full adherence per patient increased over time. Controlling for covariates, suboptimal adherence at first surveillance (HRs 2.19 and 1.79 for partial adherence and non-adherence, respectively), but not at any time point, increased the risk of HCC or death.

conclusionsWe observed improvements in HCC surveillance adherence after US LI-RADS implementation. Higher adherence was associated with hepatology care engagement, but lower in those with alcohol or tobacco use, with initial surveillance non-adherence increasing the risk of HCC or death. These findings underscore the role of expanded specialty care access and early targeted interventions, especially in those with behavioral health risks, to enhance HCC surveillance.

Indexed as

LI-RADSLiver cancerLow socioeconomic statusPrimary careScreening

Identifiers

PMID42665747

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.