ArticleNPJ precision oncology2026
Integrative pan-cancer and COAD-focused multi-omics analysis of non-histone acetylation substrate-related transcriptional landscapes.
Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-histone acetylation regulates protein stability, transcription, and immune signaling, yet its substrate-specific roles in colon adenocarcinoma (COAD) remain unclear. We performed an integrative multi-omics analysis to characterize acetylation substrate-related transcriptional signatures and their clinical relevance. Expression patterns and prognostic impacts of 33 acetylation-related enzymes were evaluated pan-cancer, and substrate-related networks were computationally inferred. A 15-gene substrate expression-based acetylation substrate-related imbalance score (AIScore) stratified COAD patients into prognostically distinct groups. Single-cell RNA sequencing and spatial transcriptomics revealed AIScore-high malignant cells preferentially interacting with SPP1-positive macrophages, forming immunosuppressive niches with reduced predicted immunotherapy response. Exploratory deep learning-based pathomics of whole-slide images, including ResNet-50 feature extraction, PCA, clustering, and Grad-CAM visualization, highlighted AIScore-associated morphologic hotspots at tumor-immune interfaces. These findings indicate that non-histone acetylation substrate-related transcriptional programs in COAD are linked to poor prognosis and spatial immune heterogeneity, while pathomics provides supportive morphology-linked evidence requiring further validation.
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