ArticleIn vivo (Athens, Greece)
Colitis Ameliorates Murine Autoimmune Cholangitis Through Polarization of M2 Macrophages and Inhibition of CD8
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimPrimary biliary cholangitis (PBC) is a form of chronic autoimmune cholangitis of enigmatic etiology and pathogenesis. While numerous studies indicate an association between inflammatory bowel disease (IBD) and PBC, the bidirectional impact on disease progression remains unclear. This study investigated the role of colitis in PBC progression using a mouse model of IBD-PBC. MATERIALS AND
methodsAcute experimental colitis was induced using dextran sodium sulfate in transgenic mice with PBC to establish an IBD-PBC model. Colon and liver tissues were analyzed by histopathology, flow cytometry, and immunostaining. Inflammatory mediators and metabolomic changes were further evaluated using quantitative real-time polymerase chain reaction and untargeted metabolomics.
resultsWe found that acute experimental colitis exacerbated colonic injury in PBC mice but concurrently attenuated hepatic inflammation. This hepatic effect was characterized by reduced liver-infiltrating lymphocytes (particularly CD8
conclusionCollectively, these findings suggest that experimental acute colitis may promote hepatic M2 macrophage polarization in mice with PBC, potentially through modulation of specific metabolites, thereby inhibiting CD8
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