ArticleIn vivo (Athens, Greece)
Increased Risk of Asthma in Children After Appendectomy: A Nationwide Population-based Cohort Study.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimAppendectomy is a frequently performed surgical procedure, but its impact on immune function and gut microbiota remains unclear. Asthma, a chronic disease common in childhood, is linked to dysbiosis and immune dysregulation. This study aimed to assess asthma risk in children following appendectomy. PATIENTS AND
methodsWe analyzed 3,848 patients who had undergone appendectomy between 2000 and 2018 from Taiwan's National Health Insurance Research Database and matched them with 15,392 patients who had not undergone appendectomy. Propensity score-matching balanced age and sex at a 1:4 ratio. Multiple Cox regression and subgroup analysis were performed to investigate the relative risk of developing asthma following appendectomy.
resultsAdjusted for age and sex, appendectomy patients had a higher asthma risk [relative risk=1.23, 95% confidence interval (CI)=1.01-1.50;
conclusionThese findings underscore the potential for the absence of the vermiform appendix to be associated with an increased risk of developing asthma, particularly in those aged 12-18 years. Pediatricians should be mindful of the possibility of asthma in children who have undergone appendectomy.
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