Evidence map›Paper›PMID 42665412›Full record

ArticleIn vivo (Athens, Greece)

Composite Coating-driven Regulation of

Tonya D Andreeva, Kim Burkhardt, Ole Jung, Sebastian Stammkötter, Sanja Stojanović, Stevo Najman, Frank Walther, Rumen Krastev, Mike Barbeck

Abstract read
PubMed Full text at PMC Publisher
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Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tonya D AndreevaFaculty Life Sciences, Reutlingen University, Reutlingen, Germany.
Kim BurkhardtClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
Ole JungClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
Sebastian StammkötterChair of Materials Test Engineering (WPT), TU Dortmund, Dortmund, Germany.
Sanja StojanovićDepartment for Cell and Tissue Engineering, Scientific Research Center for Biomedicine, Faculty of Medicine, University of Niš, Niš, Serbia.
Stevo NajmanDepartment for Cell and Tissue Engineering, Scientific Research Center for Biomedicine, Faculty of Medicine, University of Niš, Niš, Serbia.
Frank WaltherFaculty Life Sciences, Reutlingen University, Reutlingen, Germany.
Rumen KrastevFaculty Life Sciences, Reutlingen University, Reutlingen, Germany; rumen.krastev@reutlingen-university.de.
Mike BarbeckClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimMagnesium-based alloys are promising materials for fabrication of bioresorbable medical devices. The application is limited by rapid degradation and associated adverse tissue responses. In this study, nanometer-thin composite polyelectrolyte/wax (PEM/W) coatings were fabricated on magnesium-based implant prototypes to delay their degradation. MATERIALS AND

methodsCoatings were applied using a layer-by-layer technique. Cytocompatibility was assessed according to DIN ISO 10993-5 using NIH/3T3 fibroblasts and human umbilical vein endothelial cells (HUVECs). Degradation behavior was monitored by high-resolution micro-computed tomography (μ-CT), while tissue compatibility and host responses were evaluated histologically following DIN EN ISO 10993-6.

resultsThe coatings were continuous, hydrophobic (water contact angles exceeding 100°), with sub-micrometer thicknesses and were found to improve

conclusionOverall, composite PEM/W coatings, especially those based on natural polyelectrolytes, represent a promising surface-engineering strategy for improving the safety and performance of resorbable magnesium implants.

Indexed as

Coated Materials, BiocompatibleMagnesiumAbsorbable ImplantsAnimalsHumansHuman Umbilical Vein Endothelial CellsMaterials TestingMiceNIH 3T3 CellsRatsX-Ray MicrotomographyCoated Materials, BiocompatibleMagnesiumbiofunctionalizationcomposite coatingshistopathological analysishydrophobic coatingsin vivo degradationMagnesium biomaterialstissue response

Identifiers

PMID42665412
PMCPMC13531176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.