ArticleIn vivo (Athens, Greece)
Unmasking a B-Cell Linkage Phenotype in Severe Acute Meningoencephalitis: A Case Report of IVIG and HydroBox-assisted Immunomodulatory Therapy.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimSevere acute meningoencephalitis is a life-threatening neurological condition frequently associated with excessive inflammation, immune dysregulation, and secondary immune dysfunction. Immune exhaustion and abnormal immune cell remodeling may contribute to persistent inflammation and impaired recovery. Molecular hydrogen has emerged as a potential adjunctive therapy due to its selective antioxidant and immunomodulatory properties. CASE REPORT: A previously healthy 30-year-old male developed fulminant acute meningoencephalitis complicated by coma, respiratory failure, and severe systemic inflammation. Longitudinal immune profiling revealed profound immune dysregulation, including extensive T-cell exhaustion-associated phenotypes, abnormal regulatory T-cell remodeling, and marked humoral immune activation. The patient demonstrated widespread expression of inhibitory immune checkpoint markers, accompanied by excessive plasmablast expansion and impaired antibody homeostasis. A combined therapeutic strategy consisting of standard intensive care, intravenous immunoglobulin (IVIG), and molecular hydrogen-based adjunctive therapy (HydroBox strategy) was initiated. Following intervention, systemic inflammation rapidly resolved, immune profiles progressively normalized, and neurological function recovered completely.
conclusionThis case highlights the dynamic relationship between acute neuroinflammation and systemic immune remodeling in severe meningoencephalitis. Longitudinal immunophenotyping may provide valuable insights into disease-associated immune dysfunction and therapeutic response. The combination of IVIG and molecular hydrogen-based adjunctive therapy may represent a potential strategy for restoring immune homeostasis in critical neuroinflammatory conditions, warranting further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.