Evidence map›Paper›PMID 42665409›Full record

ArticleIn vivo (Athens, Greece)

Successful Management of Ultra-high-risk Mixed Ovarian Germ Cell Tumor Using a Pediatric-inspired Intensive Chemotherapy Regimen: A Case Report.

Juhun Lee, Hyun Jung Lee, Seung Ho Song, Seo Young Park, Dong Ja Kim, In Hee Lee, Meerim Park, Myong Cheol Lim, Sang-Yoon Park, Ji Hyun Kim

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juhun LeeDepartment of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Hyun Jung LeeDepartment of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Seung Ho SongDepartment of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Seo Young ParkDepartment of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
Dong Ja KimDepartment of Forensic Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
In Hee LeeDepartment of Hematology/Oncology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
Meerim ParkDepartment of Pediatrics, Center for Pediatric Cancer, National Cancer Center, Goyang, Republic of Korea.
Myong Cheol LimCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea.
Sang-Yoon ParkCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea.
Ji Hyun KimCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea jihyunkim@ncc.re.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimNon-gestational ovarian choriocarcinoma is an extremely aggressive malignancy with limited standardized treatment protocols. We present a successful multidisciplinary approach for a high-risk mixed malignant ovarian germ cell tumor (MOGCT) containing a predominant choriocarcinomatous component. CASE REPORT: A 33-year-old woman presented with acute hemoperitoneum. Pathology confirmed a mixed MOGCT (60% dysgerminoma, 40% choriocarcinoma, focal yolk sac tumor), International Federation of Obstetrics and Gynecology stage IVB. Following optimal cytoreductive surgery, a multidisciplinary tumor board, incorporating pediatric oncology paradigms, initiated a dose-dense, modified regimen of cyclophosphamide, bleomycin, etoposide, cisplatin, and methotrexate (Cy-BEP-MTX), administered every 2 weeks. This intensified strategy aimed to suppress rapid tumor repopulation. The patient tolerated seven cycles of this therapy and achieved complete remission, currently maintaining progression-free survival for 3 years.

conclusionFor ultra-high-risk non-gestational ovarian choriocarcinoma, optimal surgery followed by a pediatric-inspired, dose-dense chemotherapy regimen may provide a superior curative chance compared to standard protocols for adults, highlighting the value of interdisciplinary collaboration.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsNeoplasms, Germ Cell and EmbryonalOvarian NeoplasmsAdultBleomycinCisplatinCombined Modality TherapyFemaleHumansMethotrexateTreatment OutcomeBleomycinCisplatinMethotrexatedose-dense Cy-BEP-MTX regimenmixed malignant ovarian germ cell tumormultidisciplinary tumor boardNon-gestational ovarian choriocarcinomapediatric-inspired chemotherapy

Identifiers

PMID42665409
PMCPMC13531172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.