ArticleIn vivo (Athens, Greece)
An Improved Rat Model of Myocardial Infarction Without Invasive Intubation.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
BACKGROUND/
aimThe standard surgical procedure for inducing myocardial infarction (MI) in rat models via left anterior descending (LAD) coronary artery ligation typically requires invasive endotracheal intubation. While recent techniques have avoided intubation, they necessitate completing the ligation within a critically short period of less than five minutes. In this study, we developed an improved, simple and safe mask ventilation technique to extend this crucial timeframe. MATERIALS AND
methodsMale Sprague-Dawley rats (6-8 weeks old) were anesthetized with isoflurane and ventilated using a custom size syringe mask. A high-viscosity ultrasound gel was used to create an airtight seal and prevent air leaks. Ventilation pressure was maintained between 8-12 cmH
resultsThe MI group demonstrated a significant reduction in ejection fraction one week after surgery. The average infarct size was 27.1±3.45% in the MI group. Post-operative mortality was comparable between the MI and sham control groups.
conclusionThis improved mask ventilation technique provides a simple and effective method for inducing reproducible MI in rats. It allows a substantially longer procedural time duration (~10 min) for careful and effective LAD ligation intervention and, eliminating the need for complex endotracheal intubation while maintaining a high survival rate.
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