ArticleIn vivo (Athens, Greece)
Identification of Factors Associated With Clinically Problematic Hiccups in Male Patients Receiving Cisplatin-based Treatment With Dexamethasone and Aprepitant: A Subgroup Analysis.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimHiccups frequently occur during cisplatin (CDDP)-based treatment, and dexamethasone and neurokinin-1 receptor inhibitors may also induce these symptoms. We have previously reported that male sex is a significant risk factor for clinically problematic hiccups in patients receiving CDDP-based chemotherapy with these antiemetics. This study aimed to further evaluate factors associated with the symptoms in male patients receiving CDDP, dexamethasone, and aprepitant through a subgroup analysis. PATIENTS AND
methodsMale patients with thoracic cancer who received their first cycle of CDDP-based treatment (≥75 mg/m
resultsThe incidence of grade ≥2 hiccups was 46.8%, while the overall incidence of hiccups of any grade was 60.8%, including 8.1% grade 3 cases. The median time to symptom onset was two (range=1-5) days, and the median duration was two (range=1-12) days. Most patients (97.7%) received metoclopramide as first-line treatment, with an efficacy rate of 55.3%. Efficacy rates were 76.1% for baclofen, 86.4% for chlorpromazine, and 50.0% for Shakuyaku-Kanzo-To. Multivariable logistic regression analysis showed that hypoalbuminemia and concomitant bevacizumab use were significant risk factors for grade ≥2 hiccups [adjusted odds ratio (95% confidence interval)=2.53 (1.06-6.03),
conclusionHypoalbuminemia and concomitant bevacizumab use are significant risk factors for clinically problematic hiccups in male patients receiving CDDP-based treatment with dexamethasone and aprepitant for thoracic cancer.
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