ArticleIn vivo (Athens, Greece)
Perioperative Nutritional Changes Predict Adjuvant S-1 Dose Intensity in Resectable Pancreatic Cancer.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimMaintaining treatment intensity is important during adjuvant S-1 chemotherapy for resectable pancreatic cancer; however, factors associated with reduced relative dose intensity (RDI) during adjuvant chemotherapy (AC) remain unclear. This study investigated the association between perioperative inflammatory and nutritional indices and the RDI of S-1 during AC. PATIENTS AND
methodsThis retrospective single-center study included 69 patients with resectable pancreatic cancer who underwent adjuvant S-1 chemotherapy following neoadjuvant chemotherapy (NAC) and pancreatectomy between November 2019 and February 2025. Patients were classified according to AC S-1 RDI (≥80%
resultsAC S-1 RDI was significantly associated with overall survival and recurrence-free survival (both
conclusionNutritional status at AC initiation and perioperative changes in nutritional status were associated with maintenance of AC S-1 RDI in patients with resectable pancreatic cancer. The GNRI at AC initiation may be useful for assessing the risk of reduced S-1 RDI during AC.
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