ArticleIn vivo (Athens, Greece)
Real-world Feasibility of Adjuvant Nivolumab for High-risk Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimAdjuvant nivolumab is an important postoperative option for high-risk muscle-invasive urothelial carcinoma, but upper tract urothelial carcinoma (UTUC)-specific real-world evidence remains limited. This study evaluated oncologic outcomes, feasibility, and safety of adjuvant nivolumab after radical nephroureterectomy in patients with high-risk UTUC. PATIENTS AND
methodsWe retrospectively analyzed 21 consecutive patients with high-risk UTUC who received adjuvant nivolumab at the Kansai Medical University group between April 2022 and March 2025. Metastasis-free survival (MFS), overall survival (OS), treatment completion, and treatment-related adverse events (AEs) were assessed. Survival was estimated using the Kaplan-Meier method.
resultsThe median age was 76 years, and 14 patients (66.7%) had received neoadjuvant chemotherapy. The median follow-up from nivolumab initiation was 744 days. Median MFS and OS were not reached. The 12- and 24-month MFS rates were both 80.1%, while the 12- and 24-month OS rates were 90.0% and 84.4%, respectively. The median treatment duration was 34 weeks, and 10 patients (47.6%) completed the planned 48-week course. Any treatment-related AE occurred in nine patients (42.9%), and seven discontinued treatment because of grade 3 AEs.
conclusionThis early real-world study suggests that adjuvant nivolumab is feasible and may provide favorable short-term disease control in selected patients with high-risk UTUC after radical nephroureterectomy. These findings support its potential role as a postoperative option for selected patients, particularly when delivery of additional platinum-based therapy is difficult.
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