Evidence map›Paper›PMID 42665373›Full record

ArticleIn vivo (Athens, Greece)

Salivary Metabolomics: A Pilot Study for Screening Biomarkers in Mild-to-moderate Periodontitis.

Kaoru Edamatsu, Shigeo Ishikawa, Masahiro Sugimoto, Naoki Okuyama, Kazuyuki Yusa, Kenichiro Kitabatake, Tomoharu Hemmi, Mitsuyoshi Iino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaoru EdamatsuDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Shigeo IshikawaDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan; shigeo_ishikawa2011@yahoo.co.jp.
Masahiro SugimotoInstitute for Advanced Biosciences, Keio University, Yamagata, Japan.
Naoki OkuyamaDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Kazuyuki YusaDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Kenichiro KitabatakeDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Tomoharu HemmiDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Mitsuyoshi IinoDepartment of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study aims to identify salivary metabolites that can discriminate patients with mild and moderate periodontitis from healthy controls through comprehensive metabolomic analyses using capillary electrophoresis-mass spectrometry (CE-MS). PATIENTS AND

methodsForty healthy controls, 40 patients with mild periodontitis, and 40 patients with moderate periodontitis were enrolled. Whole unstimulated saliva samples were collected from the participants, and CE-MS was used to comprehensively analyze salivary metabolites. Furthermore, a multiple logistic regression (MLR) model was developed using multiple candidate metabolites, and the combinations of metabolites with the highest area under the curve (AUC) were identified.

resultsThe concentrations of 34 metabolites significantly differed between the mild/moderate periodontitis group and healthy controls. Of these, three were used to develop the MLR model: O-acetylcarnitine, tyrosine, and histidine. The AUC value based on the combination of these three metabolites was 0.867 (sensitivity: 0.73, specificity: 0.90, 95% confidence interval=0.804-0.929,

conclusionSalivary metabolites, including O-acetylcarnitine, tyrosine, and histidine, may serve as potential non-invasive biomarkers for mild-to-moderate periodontitis.

Indexed as

BiomarkersMetabolomeMetabolomicsPeriodontitisSalivaAdultCase-Control StudiesFemaleHumansMaleMass SpectrometryMiddle AgedPilot ProjectsROC CurveBiomarkersMetabolomicsmild-to-moderate periodontitissalivascreening

Identifiers

PMID42665373
PMCPMC13531121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.